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Dr. McCauliffe grew up in West Pawlet, VT and Granville, NY. After graduating from RPI and Albany
Medical College he completed a three-year training program in internal
medicine and then served back a scholarship obligation with the Air
Force. He subsequently completed
specialty training in dermatology including a dermatology residency and immunodermatology
research fellowship at the University of Texas Southwestern Medical Center in
Dallas, TX. Dr. McCauliffe then
became a faculty member of the Dermatology Department at the University of
North Carolina in Chapel Hill, NC.
After nine years in NC he returned “home” to take over the dermatology
practice of Dr. Donald McIntyre in Rutland, VT. |
Education
/ Postgraduate Training:
1970-73 Granville High School, Granville, NY
- Valedictorian
1973-77
Rensselaer
Polytechnic Institute, Troy, NY
BS-Biology,
1977 – graduated with Highest Academic Honors
1977-81
Albany Medical College,
Albany, NY – Dean’s Letter of Commendation
for Academic Excellence
MD,
1981
1981-84 Internal Medicine Residency
Wright-Patterson
AFB Medical Center, Dayton, OH
1987-91
Dermatology
Residency and Immunodermatology Research Fellowship
University of Texas
Southwestern Medical Center, Dallas, TX
Military
Service:
1984-86
Chief of Medicine, Director
of Medical Education, Director of Emergency Care Services, USAF Hospital, Grand
Forks AFB, ND
1986-87 Staff Internist, USAF Medical Center,
Scott AFB, IL
Academic Positions:
1985-86 Clinical
Assistant Professor of Medicine
University
of North Dakota Medical School, Grand Forks, ND
1990-91 Research
Assistant Professor of Dermatology
University
of Texas Southwestern Medical Center, Dallas, TX
1991-96 Assistant
Professor of Dermatology
University
of North Carolina, Chapel Hill, NC
1996-2000
Associate Professor of Dermatology
University
of North Carolina, Chapel Hill, NC
Board Certifications:
National Board of Medical Examiners
American Board of Internal Medicine
American Board of Dermatology
Professional Societies:
American Academy of Dermatology, 1991 -
American Federation for Clinical Research, 1991 - 2000
Society of Investigative Dermatology, 1992 -
American College of Rheumatology, 1993 -
North Carolina Dermatology Association, 1996 - 2000
American Association for the Advancement of Science, 1996 -
2000
Dermatology Foundation Leaders Society, 1997 –
Vermont Medical Society
Professional Awards:
US Air Force Health Professional
Scholarship (1978-81), Upjohn Research Award, in recognition for outstanding
research in dermatology (1988), Young Investigator Award, Clinical Dermatology
in the Year 2000 (1990), Dermatology Foundation - Career Development Award
(1990-2), University of North Carolina Junior Faculty Development Award (1992),
National Institutes of Health FIRST Award (1993-7), National Institutes of
Health R01 Award (1995-8)
1. Medical
dermatology including the evaluation and treatment of pediatric and adult
diseases of the skin, hair and nails
2. Surgical
dermatology including surgical excisions, laser treatment and repairs of skin
lesions and defects
3. Aesthetic
dermatology including botulinum toxin (BotoxÒ) for rhytids and hyperhidrosis; sclerotherapy; vascular laser
treatment of cutaneous vascular lesions; and laser skin resurfacing
4. Attending and
consultant work on hospitalized patients with cutaneous disease
5.
Teaching of medical students, dermatology residents and residents
in other specialties, and primary care physicians
6.
Past Director of the University of North Carolina Dermatology
Clinics, and Current Director of the Rutland Skin Center
International, National and Regional
Lectures Presented by Dr. McCauliffe:
(excludes local lectures)
1991 - American
Academy of Dermatology, Dallas, TX; Introductory Allergy and Immunology Course:
Cutaneous Lupus Erythematosus
1992 - American
Academy of Dermatology, San Francisco, CA; Introductory Allergy and Immunology
Course
- World
Congress of Dermatology, New York, NY; Lupus Erythematosus Symposium
- Area Health Education Center (AHEC), Ashboro,
NC; Cutaneous Lupus Erythematosus
- AHEC, Charlotte, NC; Cutaneous Lupus
Erythematosus
1993 - American
Academy of Dermatology, Washington, DC; Practical Management of Patients with
Collagen Vascular Disease Symposium
- AHEC, Charlotte, NC; Molecular dermatology
1994 - Invited Guest Speaker - 4th Annual UNC/Duke Rheumatology Update, Research
Triangle Park, NC; Cutaneous Lupus Erythematosus
- AHEC, Charlotte, NC; Ro/SS-A
Autoantibodies
- Invited
Guest Speaker - Japanese Society for
Investigative Dermatology, National Meeting, Osaka, Japan; Similarities in
Autoantibody Response in Annular Erythema of Sjogren’s Syndrome and Subacute
Cutaneous Lupus Erythematosus
1995 - Southeastern
Consortium for Dermatology, Chapel Hill, NC; Patient Case Presentations
1996 - AHEC,
Charlotte, NC; Teledermatology, Interesting Dermatology Cases
1997 - AHEC,
Burlington, NC; What’s New in Dermatology
- AHEC, High Point, NC; Cutaneous Manifestations
of Systemic Disease
- American Academy of Dermatology Meeting, Washington D.C.;
Cutaneous Disease Associations with Ro/SS-A Autoantibodies in Adults
(Rheumatology Symposium)
- North
Carolina Dermatology Association Annual Meeting, Pinehurst, NC; Practical Value of ANA and Related Tests in the
Evaluation of Collagen Vascular Diseases
1998 - American Academy of Dermatology, Orlando, FL;
Update in Collagen Vascular
Diseases;
Autoantibody Testing - A Practical Approach for Dermatologists
- Invited Guest Speaker - International Neonatal Lupus Erythematosus
Symposium, Milan, Italy; Conventional Ro/SS-A Serologic Assays Fail to Detect
Anti-52 kD Ro/SS-A Autoantibodies; Cutaneous Diseases Associated With the
Ro/SS-A Autoimmune Response
- AHEC, Henderson, NC; Dermatology Update
- Invited Guest Speaker - Pan-American Congress of Rheumatology, Montreal,
Canada; Management of Refractory Cutaneous Lupus Erythematosus
- Invited Guest Speaker - Medicine Grand Rounds, Mary Imogene Bassett Medical
Center, Cooperstown, NY; Practical Value of ANA and Related Tests in the
Evaluation of Collagen Vascular Disorders
-
Invited Guest Speaker –
Dermatology Symposium, NC State University – College of Veterinary Medicine;
Cutaneous Lupus Erythematosus
-
Invited Guest Speaker –
New Zealand Dermatology Society Meeting, Port Vila, Vanuatu; Cutaneous Lupus
Erythematosus; Antinuclear Antibody Testing – A Dermatologist’s Perspective;
Dermatomyositis; Neonatal Lupus Erythematosus and Other Ro/SS-A
Autoantibody-Associated Cutaneous Disorders
1999 - Invited Guest Speaker –
Grand Rounds, St. Paul Medical Center, Dallas, TX: Diagnosing
and Managing Cutaneous Lupus Erythematosus
- American Academy
of Dermatology, New Orleans, LA; Update in Collagen Vascular
Diseases; ANA Testing - A Practical Approach for
Dermatologists; Rheumatology
Symposium-Cutaneous diseases associated with
anti-Ro/SS-A autoantibodies
-
Invited Guest Speaker –
CAPS 1999 Continuing Education Seminar, Durham, NC: Dermatology Update;
Fundamental Skin Disease Assessment
-
Invited Speaker - North Carolina Dermatology Association
Annual Meeting, Research Triangle Park, NC: Dermatologic uses of Botulinum
Toxin
2000 - Invited Guest Speaker - Department of Dermatology, University of Iowa, Iowa
City, IA:
Dermatomyositis, Diagnosis and
Management; Practical Value of ANA Testing
- American Academy of Dermatology, San
Francisco, CA: Internal Medicine Course –
Lupus Erythematosus and
Scleroderma; Rheumatology Symposium – Autoantibody
Detection Assays: What to Order;
Cutaneous Lupus Erythematosus
2001 - American
Academy of Dermatology, Washington, DC: Internal Medicine Course –
Lupus Erythematosus and Scleroderma
- Duke University Medical Center,
Durham, NC: Cutaneous Lupus Erythematosus
Archives of Dermatology
Clinical and Experimental
Immunology
Journal of the American Academy of
Dermatology
Journal of Clinical Investigation
Journal of Immunology
Journal of Investigative Dermatology
Journal of Musculoskeletal Medicine
Journal of Pediatrics
Journal of Rheumatology
Lancet
Lupus
New England Journal of Medicine
Scandinavian Journal of Rheumatology
Publications:
Journal Articles and Book Chapters
1.
McCauliffe DP, Lux FA, Lieu
TS, Sanz I, Hanke J, Newkirk M, Siciliano MJ, Sontheimer RD and Capra JD. 1989.
Ro/SS-A and the pathogenic significance of its antibodies. J Autoimmunity 2:375-81, 1989.
2.
Lieu TS, McCauliffe DP,
Newkirk MM, Arnett FC, Lee LA, Deng JS, Capra JD, Sontheimer RD: A major
autoepitope is present on the amino terminus of the human Ro/SS-A polypeptide. J Autoimmunity 2:367-374, 1989.
3.
McCauliffe DP, Lux FA, Lieu
TS, Sanz I, Hanke J, Newkirk MM, Bachinski LL, Itoh Y, Siciliano MJ, Reichlin
M, Sontheimer RD, Capra JD: Molecular cloning, expression and chromosome 19
localization of a human Ro/SS-A autoantigen. J Clin Invest 85:1379-91, 1990.
4.
McCauliffe DP, Lieu TS,
Michalak M, Sontheimer RD, Capra JD: A human Ro/SS-A autoantigen is the
homologue of calreticulin and is highly homologous with onchocercal Ral-1
antigen and an aplysia memory molecule. J
Clin Invest 86:332-335, 1990.
5.
Sontheimer RD, McCauliffe DP.
Pathogenesis of anti-Ro/SS-A autoantibody- associated cutaneous lupus
erythematosus. Dermatology Clinics
8:751-758, 1990.
6.
Sontheimer RD, Lieu T-S,
McCauliffe DP. Molecular Characterization of the Ro/SS-A autoimmune response. Seminars in Dermatology 10:199-205,
1991.
7.
McCauliffe DP and Poitras K.
Aspartame-induced lobular panniculitis. J
Am Acad Dermatol 24:298-300, 1991.
8.
McCauliffe DP, Yang YS,
Wilson J, Sontheimer RD, Capra JD. The 5' flanking region of the human
calreticulin gene is highly homologous with the human GRP78, GRP94 and protein
disulfide isomerase promoters. J Biol
Chem 267:2557-2562, 1992.
9.
McCauliffe DP, Sontheimer RD.
Subacute cutaneous lupus erythematosus.
In: Wallace DJ and Hahn BH, editors. Dubois' Lupus Erythematosus.
Philadelphia, Lea & Febiger, 302-309, 1992.
10. Sontheimer RD, McCauliffe DP, Zappi E, Targoff IN. The fine
specificity of rheumatic disease-associated autoantibodies. Advances in Dermatology 7:3-52, 1992.
Chicago: Year Book Medical Publishers, Inc.
11. Black AA, McCauliffe DP, Sontheimer RD. Prevalence of acne
rosacea in a rheumatic skin disease subspecialty clinic. Lupus 1:229-237, 1992.
12. Lux FA, McCauliffe DP, Buttner DW, Capra JD, Sontheimer RD,
Lieu TS. Serologic cross-reactivity between a human Ro/SS-A autoantigen
(calreticulin) and the Ral-1 antigen of Onchocerca
volvulus. J Clin Invest
89:1945-1951, 1992.
13. McCauliffe DP, Sontheimer RD. Molecular studies of the
Ro/SS-A autoantigens. Pages 798-804 In:
Dermatology Progress & Perspectives;
eds: Burgdorf WHC and Katz SI.
Parthenon Publishing Group, Inc., Pearl River, New York, 1992.
14. McCauliffe DP, Sontheimer RD. Molecular characterization of
the Ro/SS-A autoantigens. J Invest Dermatol 100:73S-79S, 1993.
15. McCauliffe DP and Sontheimer RD. Dermatologic
Manifestations of Rheumatic Disorders. Primary
Care 20:925-941, 1993.
16. McCauliffe DP, Lupus erythematosus-specific cutaneous
disease. Keio J Med 43:225, 1994.
17. McCauliffe DP, Yin Y, Wang L, Lucas L. Autoimmune sera
react with multiple epitopes on recombinant 52 and 60 kD Ro/SS-A proteins. J Rheumatol 21:1073-1080, 1994.
18. Satoh M, Langdon JJ, Chou CH, McCauliffe DP, Treadwell EL,
Ogasawara T, Hirakata M, Suwa A, Cohen PL, Eisenberg RA, Reeves WH.
Characterization of the Su antigen, a macromolecular complex of 100/102 and 200-kDa
proteins recognized by autoantibodies in systemic rheumatic diseases. Clin Immunol Immunopathol 73:132-141,
1994.
19. McCauliffe, DP. The autoantibodies of neonatal lupus
erythematosus. J Invest Dermatol
102: 827, 1994.
20. McCauliffe DP. Neonatal Lupus Erythematosus: A
transplacentally acquired autoimmune disorder. Semin Dermatol 14: 47-53, 1995.
21. McCauliffe DP, Faircloth E, Wang L, Hashimoto T, Hoshino Y,
Nishikawa T. Similar Ro/SS-A autoantibody epitope and titer responses in
annular erythema of Sjogren’s syndrome and subacute cutaneous lupus
erythematosus. Arch Dermatol
32:528-531, 1996.
22. Yell JA, Wang L, Yin H, McCauliffe DP. Disparate locations
of the 52 and 60 kD Ro/SS-A antigens in cultured human keratinocytes. J Invest Dermatol 107:622-626, 1996.
23. McCauliffe, DP.
Antibody penetration into the cells of mice and men. J Invest Dermatol 107:3-4, 1996.
24. McCauliffe DP, Sontheimer RD. Cutaneous lupus
erythematosus. Pages 67-82. In: The
Clinical Management of Systemic Lupus Erythematosus, Ed: Schur PH.
Lippincott-Raven Publishers, New York, 1996.
25. McCauliffe DP, Wang L, Satoh M, Reeves WH, Small D. A recombinant 52 kD Ro(SS-A) ELISA detects
autoantibodies in Sjogren’s Syndrome sera that go undetected by conventional
serologic assays. J Rheumatol
24:860-6, 1997.
26. McCauliffe DP. Cutaneous associations of anti-Ro/SS-A
autoantibody production in adults. Lupus 6:158-166, 1997.
27. Skidmore RA, Davis DA, Woosley JT and McCauliffe DP.
Massive dystrophic calcinosis cutis secondary to chronic needle trauma. Cutis 60:259-62, 1997.
28. McCauliffe DP. Distinguishing subacute cutaneous from other
types of lupus erythematosus. Lancet
351:1527-8, 1998.
29. Franceschini F, Calzavara-Pinton P, Quinzanini M, Cavazzana
I, Bettoni L, Zane C, Facchetti F, Airò P, McCauliffe DP, Cattaneo R. Chilblain lupus erythematosus is associated
with antibodies to SSA/Ro. Lupus 8:215-219,
1999.
30. Gahli F, Groben P, McCauliffe DP. Panniculitis in juvenile
dermatomyositis. Pediatr Dermatol,
16:270-2, 1999.
31. Gahli F., Stein L, McCauliffe DP. Rediscovery of gingival
telangiectasias as a cutaneous marker for juvenile dermatomyositis. Arch Dermatol 135:1370-74, 1999.
32. McCauliffe DP. Neonatal Lupus Erythematosus, In: Textbook of Paediatric Dermatology,
edited by Harper J, Oranje A, and Prose N. Blackwell Science Ltd, Oxford. Pages
111-6, 2000.
33. Jewell M, McCauliffe DP.
Cutaneous lupus erythematosus patients that smoke are less responsive to
antimalarial treatment. J Am Acad Dermatol 42:983-7, 2000.
34. Morrell DS, Ghali FE, Stahr BJ, McCauliffe DP. Eccrine
angiomatous hamartoma: A report of symmetric and painful lesions of the
wrists. Pediatr Dermatol
18:117-9, 2001.
35. McCauliffe DP. Cutaneous lupus erythematosus. Semin
Cutan Med Surg 20:14-26, 2001.
36. McCauliffe DP, Sontheimer RD. Cutaneous lupus erythematosus.
In: Wallace DJ and Hahn BH, editors. Dubois' Lupus Erythematosus, 5th edition. Philadelphia. Lippincott, Williams
& Wilkins, in press, 2001.
37. Wozniacka A, Carter A, McCauliffe DP. Mechanisms by which
antimalarials may provide therapeutic benefit in cutaneous lupus erythematosus.
Lupus, in press, 2001.
38. McCauliffe DP, Lieu TS, Sontheimer RD. An enzyme-linked
immunosorbent assay (ELISA) inhibition technique for quantifying Ro/SS-A
antigen in skin and other types of human tissue. Clin Res 36:673A, 1988.
39. McCauliffe DP, Lieu TS, Sanz I, Hanke J, Newkirk M,
Sontheimer RD, Capra JD. Structural, immunological and molecular genetic
studies of the Ro/SS-A (Ro) polypeptide. Clin
Res 36:377A, 1988.
40. McCauliffe DP, Lieu T-S, Sanz I, Hanke J, Newkirk M, Capra
JD, Sontheimer RD. Immunological and molecular genetic studies of the Ro/SS-A
polypeptide. Clin Res 37:79A, 1989.
41. Lieu T-S, McCauliffe DP, Capra JD, Sontheimer RD. Structure
and epitope study of human Ro/SS-A antigen. FASEB J 3:A491, 1989.
42. Lieu T-S, McCauliffe DP, Arnett FC, Lee LA, Deng J-S, Capra
JD, Sontheimer RD. Epitope mapping of the human Wil-2 cell Ro/SS-A
autoantigenic polypeptide. Clin Res
37:662A, 1989.
43. McCauliffe DP, Lieu T-S, Capra JD, Sontheimer RD. The
gemomic configuration of a human Ro/SS-A gene. Clin Res 37:758A, 1989.
44. Lieu T-S, McCauliffe DP, Volpe P, Alderson-Lang BH,
Michalak M, Capra JD, Sontheimer RD: Structural and Functional Homology Between
a Human Ro/SS-A (Ro) Autoantigen and
the Calcium-binding Protein (CBP), Calreticulin (CR). Clin Res 38:408A, 1990.
45. McCauliffe DP, Lieu T-S, Kennedy T, Sontheimer RD, Capra
JD: A Human Ro/SS-A (Ro) Autoantigen is the Human Homologue of Murine
Calreticulin, Onchocercal Ral-1 Antigen, and Aplysia Protein 407. Clin Res 38:631A, 1990.
46. Zappi E, McCauliffe DP, Sontheimer RD and Capra JD: Cloning
and Sequencing of the Drosophila Homologue of a Human Ro/SS-A (Ro) Autoantigen.
Clin Res 38:633A, 1990.
47. Lux FA, McCauliffe DP, Buttner DW, Capra JD, Sontheimer RD,
Lieu T-S: Antibodies (Abs) to Onchocerca Volvulus Cross-React with a
Human Ro/SS-A (Ro) Autoantigen (Aag). Clin
Res 38:626A, 1990.
48. Lieu T-S, McCauliffe DP, Lee LA, Norris DN, Capra JD,
Sontheimer RD: Variant Epitope Binding Protein (EBP) of Drug-Induced Ro/SS-A
Autoantibodies (A-Ro). Clin Res
38:631A, 1990.
49. McCauliffe DP, Sontheimer RD, Capra JD: Characterization of
the human 46 kD Ro/SS-A autoantigen promoter region. Arthritis Rheum 33S:C131, 1990.
50. Sontheimer RD, McCauliffe DP, Michalak M, Capra JD, Lieu
TS: Cytoplasmic localization of a calcium-binding 46 kD human Ro/SS-A antigen. Arthritis Rheum, 33S:B15, 1990.
51. McCauliffe DP, Yang YS, Sontheimer RD, Capra JD.
Characterization of the promoter region of human calreticulin (the 46 kD
Ro/SS-A autoantigen). J Invest Dermatol
96:538, 1991.
52. Lieu TS, Zappi EG, McCauliffe DP, Haseman CA, Capra JD,
Sontheimer RD. Frequency of antibodies to human calreticulin in precipitating
Ro/SS-A autoantibody-positive sera. J
Invest Dermatol 96:572, 1991.
53. Zappi EG, McCauliffe DP, Haseman CA, Lieu TS, Sontheimer
RD, Capra JD. Expression of the human
46 kD Ro/SS-A autoantigen calreticulin) as a recombinant protein. J Invest Dermatol 96:561, 1991.
54. McCauliffe, DP, Gardner D. Ro/SS-A autoantibodies
reactivity with recombinant 60, 52 and 46 kD fusion proteins. J Invest Dermatol 98:630, 1992.
55. Sontheimer RD, McCauliffe DP, Wilson JL, Capra JD.
Transcriptional regulation of human calreticulin. J Invest Dermatol 98:628, 1992.
56. Lucas L, Yin H, McCauliffe DP. 52 and 60 kD Ro/SS-A
autoantigens are expressed by human keratinocytes and are reactive with
subacute cutaneous and neonatal lupus erythematosus sera. J Invest Dermatol 100:575, 1993.
57. Lowen L, McCauliffe DP. The 52 kD Ro/SS-A autoantigen binds
DNA with high affinity and is a member of a novel family of zinc finger
proteins. J Invest Dermatol 100:553,
1993.
58. Cornelius PB, McCauliffe DP. Detection of Ro/SS-A
autoantibodies in dermatomyositis sera. J
Invest Dermatol 102:635, 1994.
59. McCauliffe DP, Yin H, Wang L, Lucas L. Subacute cutaneous
and neonatal lupus erythematosus sera
react with multiple epitopes on the 52 and 60 kD Ro/SS-A autoantigens. J Invest Dermatol 102:635, 1994.
60. Yell JA, Wang L, Yin H, McCauliffe DP. The location of the
60 and 52 kD Ro (SS-A) antigens in human keratinocytes. J Invest Dermatol 104:641, 1995.
61. McCauliffe DP, Guest PJ, Folds JD. Cytoplasmic fluorescence
on routine ANA testing is frequently associated with anti-60 kD Ro/SS-A
autoantibodies. J Invest Dermatol
104:679, 1995.
62. McCauliffe DP, Wang L, Small D. A recombinant 52 kD
Ro(SS-A) ELISA detects autoantibodies in primary Sjogren’s syndrome sera that
go undetected by conventional serologic assays. Arthritis Rheum 39:S181, 1996.
63. Yell, JA, Wang, L, Yin H, McCauliffe DP. 52 and 60 kD
Ro/SS-A autoantigens have disparate intracellular locations in human
keratinocytes. Arthritis Rheum
39:S181, 1996.
64. McCauliffe DP, Wang L, Satoh M, Reeves W, Small D. Anti-52
kD Ro(SS-A) autoantibodies go undetected by conventional Ro Serologic assays. J
Invest Dermatol 108: 640, 1997.
65. Sweeny AL, McCauliffe DP.
52 Ro/SS-A protein resides along cytokeratin filaments in
epithelial
cells. J Invest Dermatol 114:856, 2000.
66. Lopez M, Wozniacka A, McCauliffe DP. 52 Ro/SS-A protein resides along
cytokeratins and other intermediate filaments. Arthritis Rheum in press,
2000.