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Dr. Daniel
P. McCauliffe’s Curriculum Vitae
Education / Postgraduate Training:
1970-73 Granville
High School, Granville, NY - Valedictorian
1973-77
Rensselaer Polytechnic
Institute, Troy, NY
BS-Biology,
1977-graduated with Highest Academic Honors
1977-81 Albany
Medical College, Albany, NY - Dean’s Letter of Commendation for Academic
Excellence
MD,
1981
1981-84 Internal
Medicine Residency
Wright-Patterson
AFB Medical Center, Dayton, OH
1987-91
Dermatology
Residency and Immunodermatology Research Fellowship University of Texas
Southwestern Medical Center, Dallas, TX
Military Service:
1984-86
Chief of Medicine,
Director of Medical Education, Director of Emergency Care Services, USAF
Hospital, Grand Forks AFB, ND
1986-87 Staff
Internist, USAF Medical Center, Scott AFB, IL
Academic Positions:
1985-86 Clinical
Assistant Professor of Medicine
University
of North Dakota Medical School, Grand Forks, ND
1990-91 Research
Assistant Professor of Dermatology
University
of Texas Southwestern Medical Center, Dallas, TX
1991-96 Assistant
Professor of Dermatology
University
of North Carolina, Chapel Hill, NC
1996-2000 Associate Professor
of Dermatology
University
of North Carolina, Chapel Hill, NC
Board Certifications:
National Board of Medical Examiners
American Board of Internal Medicine
American Board of Dermatology
Professional Societies:
American Academy of Dermatology, 1991 -
American Federation for Clinical Research, 1991 - 2000
Society of Investigative Dermatology, 1992 -
American College of Rheumatology, 1993 -
North Carolina Dermatology Association, 1996 - 2000
American Association for the Advancement of Science, 1996
- 2000
Dermatology Foundation Leaders Society, 1997 -
Vermont Medical Society
Professional Awards:
US Air Force Health Professional
Scholarship (1978-81), Upjohn Research Award, in recognition for outstanding
research in dermatology (1988), Young Investigator Award, Clinical
Dermatology in the Year 2000 (1990), Dermatology Foundation - Career
Development Award (1990-2), University of North Carolina Junior Faculty
Development Award (1992), National Institutes of Health FIRST Award
(1993-7), National Institutes of Health R01 Award (1995-8)
Professional Clinical
Activities:
1. Medical dermatology
including the evaluation and treatment of pediatric and adult diseases of
the skin, hair and nails
2. Surgical dermatology
including surgical excisions, laser treatment and repairs of skin lesions
and defects
3. Aesthetic dermatology
including botulinum toxin (BotoxŇ) for rhytids and
hyperhidrosis; sclerotherapy; vascular laser treatment of cutaneous
vascular lesions; and laser skin resurfacing
4. Attending and consultant
work on hospitalized patients with cutaneous disease
5.
Teaching of
medical students, dermatology residents and residents in other specialties,
and primary care physicians
6. Past Director of the
University of North Carolina Dermatology Clinics, and Current Director of
the Rutland Skin Center
7. Member of the Vermont
Physicians Clinic
International, National and Regional Lectures
Presented by Dr. McCauliffe:
(excludes
local lectures)
1991 - American
Academy of Dermatology, Dallas, TX; Introductory Allergy and Immunology
Course: Cutaneous Lupus Erythematosus
1992 - American Academy of Dermatology, San
Francisco, CA; Introductory Allergy and Immunology Course
- World
Congress of Dermatology, New York, NY; Lupus Erythematosus Symposium
- Area Health Education Center (AHEC),
Ashboro, NC; Cutaneous Lupus Erythematosus
- AHEC, Charlotte, NC; Cutaneous Lupus
Erythematosus
1993 - American
Academy of Dermatology, Washington, DC; Practical Management of Patients
with Collagen Vascular Disease Symposium
- AHEC,
Charlotte, NC; Molecular dermatology
1994 - Invited Guest Speaker - 4th Annual UNC/Duke Rheumatology Update, Research
Triangle Park, NC; Cutaneous Lupus Erythematosus
- AHEC,
Charlotte, NC; Ro/SS-A Autoantibodies
- Invited Guest Speaker - Japanese Society for Investigative Dermatology,
National Meeting, Osaka, Japan; Similarities in Autoantibody Response in
Annular Erythema of Sjogren’s Syndrome and Subacute Cutaneous Lupus
Erythematosus
1995 - Southeastern
Consortium for Dermatology, Chapel Hill, NC; Patient Case Presentations
1996 - AHEC, Charlotte, NC;
Teledermatology, Interesting Dermatology Cases
1997 - AHEC, Burlington, NC;
What’s New in Dermatology
- AHEC,
High Point, NC; Cutaneous Manifestations of Systemic Disease
- American Academy of Dermatology Meeting, Washington
D.C.; Cutaneous Disease Associations with Ro/SS-A Autoantibodies in Adults
(Rheumatology Symposium)
- North
Carolina Dermatology Association Annual Meeting, Pinehurst, NC; Practical Value of ANA and Related Tests in
the Evaluation of Collagen Vascular Diseases
1998 - American Academy of
Dermatology, Orlando, FL; Update in Collagen Vascular
Diseases;
Autoantibody Testing - A Practical Approach for Dermatologists
- Invited
Guest Speaker - International
Neonatal Lupus Erythematosus Symposium, Milan, Italy; Conventional Ro/SS-A
Serologic Assays Fail to Detect Anti-52 kD Ro/SS-A Autoantibodies;
Cutaneous Diseases Associated With the Ro/SS-A Autoimmune Response
- AHEC,
Henderson, NC; Dermatology Update
- Invited
Guest Speaker - Pan-American
Congress of Rheumatology, Montreal, Canada; Management of Refractory
Cutaneous Lupus Erythematosus
- Invited
Guest Speaker - Medicine Grand
Rounds, Mary Imogene Bassett Medical Center, Cooperstown, NY; Practical
Value of ANA and Related Tests in the Evaluation of Collagen Vascular
Disorders
-
- Invited Guest Speaker - Dermatology Symposium, NC State University -
College of Veterinary Medicine; Cutaneous Lupus Erythematosus
-
- Invited Guest Speaker - New Zealand Dermatology Society Meeting, Port
Vila, Vanuatu; Cutaneous Lupus Erythematosus; Antinuclear Antibody Testing
- A Dermatologist’s Perspective; Dermatomyositis; Neonatal Lupus
Erythematosus and Other Ro/SS-A Autoantibody-Associated Cutaneous Disorders
1999 - Invited
Guest Speaker - Grand Rounds, St.
Paul Medical Center, Dallas, TX: Diagnosing
and Managing Cutaneous Lupus
Erythematosus
- American Academy of Dermatology, New Orleans, LA;
Update in Collagen Vascular
Diseases; ANA Testing - A Practical Approach for Dermatologists;
Rheumatology
Symposium-Cutaneous diseases associated with anti-Ro/SS-A autoantibodies
-
- Invited Guest Speaker - CAPS 1999 Continuing Education Seminar, Durham,
NC: Dermatology Update; Fundamental Skin Disease Assessment
-
- Invited Speaker - North Carolina Dermatology
Association Annual Meeting, Research Triangle Park, NC: Dermatologic uses
of Botulinum Toxin
2000 - Invited
Guest Speaker - Department of
Dermatology, University of Iowa, Iowa City, IA:
Dermatomyositis,
Diagnosis and Management; Practical Value of ANA Testing
-
American Academy of Dermatology, San Francisco, CA: Internal Medicine
Course -
Lupus Erythematosus and Scleroderma; Rheumatology Symposium -
Autoantibody
Detection Assays: What to Order; Cutaneous Lupus Erythematosus
2001 - American Academy of Dermatology, Washington, DC:
Internal Medicine Course -
Lupus Erythematosus and Scleroderma
- Duke University Medical Center, Durham, NC: Cutaneous
Lupus Erythematosus
2002 - American Academy of Dermatology, New Orleans,
LA: Internal Medicine Course -
Lupus Erythematosus and Scleroderma
Dr. McCauliffe is a reviewer of articles before they are selected
for publication in the following journals:
Archives of Dermatology
Clinical and Experimental
Immunology
Journal of the American
Academy of Dermatology
Journal of Clinical
Investigation
Journal of Immunology
Journal of Investigative Dermatology
Journal of Musculoskeletal Medicine
Journal of Pediatrics
Journal of Rheumatology
Lancet
Lupus
New England Journal of Medicine
Scandinavian Journal of Rheumatology
Publications:
1.
McCauliffe DP, Lieu TS, Sontheimer RD. An enzyme-linked
immunosorbent assay (ELISA) inhibition technique for quantifying Ro/SS-A
antigen in skin and other types of human tissue. Clin Res 36:673A, 1988.
2.
McCauliffe DP, Lieu TS, Sanz I, Hanke J, Newkirk M, Sontheimer RD,
Capra JD. Structural, immunological and molecular genetic studies of the
Ro/SS-A (Ro) polypeptide. Clin Res
36:377A, 1988.
3.
McCauliffe DP, Lieu T-S, Sanz I, Hanke J, Newkirk M, Capra JD,
Sontheimer RD. Immunological and molecular genetic studies of the Ro/SS-A
polypeptide. Clin Res 37:79A,
1989.
4.
Lieu T-S, McCauliffe DP, Capra JD, Sontheimer RD. Structure and
epitope study of human Ro/SS-A antigen. FASEB J 3:A491, 1989.
5.
Lieu T-S, McCauliffe DP, Arnett FC, Lee LA, Deng J-S, Capra JD,
Sontheimer RD. Epitope mapping of the human Wil-2 cell Ro/SS-A
autoantigenic polypeptide. Clin Res
37:662A, 1989.
6.
McCauliffe DP, Lieu T-S, Capra JD, Sontheimer RD. The gemomic
configuration of a human Ro/SS-A gene. Clin
Res 37:758A, 1989.
7.
McCauliffe DP, Lux FA, Lieu TS, Sanz I, Hanke J, Newkirk M,
Siciliano MJ, Sontheimer RD and Capra JD. 1989. Ro/SS-A and the pathogenic
significance of its antibodies. J
Autoimmunity 2:375-81, 1989.
8.
Lieu TS, McCauliffe DP, Newkirk MM, Arnett FC, Lee LA, Deng JS,
Capra JD, Sontheimer RD: A major autoepitope is present on the amino
terminus of the human Ro/SS-A polypeptide. J Autoimmunity 2:367-374, 1989.
9.
McCauliffe DP, Lux FA, Lieu TS, Sanz I, Hanke J, Newkirk MM,
Bachinski LL, Itoh Y, Siciliano MJ, Reichlin M, Sontheimer RD, Capra JD:
Molecular cloning, expression and chromosome 19 localization of a human
Ro/SS-A autoantigen. J Clin Invest
85:1379-91, 1990.
10.
McCauliffe DP, Lieu TS, Michalak M, Sontheimer RD, Capra JD: A human
Ro/SS-A autoantigen is the homologue of calreticulin and is highly
homologous with onchocercal Ral-1 antigen and an aplysia memory molecule. J Clin Invest 86:332-335, 1990.
11.
Sontheimer RD, McCauliffe DP. Pathogenesis of anti-Ro/SS-A
autoantibody- associated cutaneous lupus erythematosus. Dermatology Clinics 8:751-758,
1990.
12.
Lieu T-S, McCauliffe DP, Volpe P, Alderson-Lang BH, Michalak M,
Capra JD, Sontheimer RD: Structural and Functional Homology Between a Human
Ro/SS-A (Ro)
Autoantigen and the Calcium-binding Protein (CBP), Calreticulin (CR). Clin Res 38:408A, 1990.
13.
McCauliffe DP, Lieu T-S, Kennedy T, Sontheimer RD, Capra JD: A Human
Ro/SS-A (Ro) Autoantigen is the Human Homologue of Murine Calreticulin,
Onchocercal Ral-1 Antigen, and Aplysia Protein 407. Clin Res 38:631A, 1990.
14.
Zappi E, McCauliffe DP, Sontheimer RD and Capra JD: Cloning and
Sequencing of the Drosophila Homologue of a Human Ro/SS-A (Ro) Autoantigen.
Clin Res 38:633A, 1990.
15.
Lux FA, McCauliffe DP, Buttner DW, Capra JD, Sontheimer RD, Lieu
T-S: Antibodies (Abs) to Onchocerca Volvulus Cross-React with a
Human Ro/SS-A (Ro) Autoantigen (Aag). Clin
Res 38:626A, 1990.
16.
Lieu T-S, McCauliffe DP, Lee LA, Norris DN, Capra JD, Sontheimer RD:
Variant Epitope Binding Protein (EBP) of Drug-Induced Ro/SS-A
Autoantibodies (A-Ro). Clin Res
38:631A, 1990.
17.
McCauliffe DP, Sontheimer RD, Capra JD: Characterization of the
human 46 kD Ro/SS-A autoantigen promoter region. Arthritis Rheum 33S:C131, 1990.
18.
Sontheimer RD, McCauliffe DP, Michalak M, Capra JD, Lieu TS:
Cytoplasmic localization of a calcium-binding 46 kD human Ro/SS-A antigen. Arthritis Rheum, 33S:B15, 1990.
19.
McCauliffe DP, Yang YS, Sontheimer RD, Capra JD. Characterization of
the promoter region of human calreticulin (the 46 kD Ro/SS-A autoantigen). J Invest Dermatol 96:538, 1991.
20.
Lieu TS, Zappi EG, McCauliffe DP, Haseman CA, Capra JD, Sontheimer
RD. Frequency of antibodies to human calreticulin in precipitating Ro/SS-A
autoantibody-positive sera. J Invest
Dermatol 96:572, 1991.
21.
Zappi EG, McCauliffe DP, Haseman CA, Lieu TS, Sontheimer RD, Capra
JD. Expression of the human 46
kD Ro/SS-A autoantigen calreticulin) as a recombinant protein. J Invest Dermatol 96:561, 1991.
22.
Sontheimer RD, Lieu T-S, McCauliffe DP. Molecular Characterization
of the Ro/SS-A autoimmune response. Seminars
in Dermatology 10:199-205, 1991.
23.
McCauliffe DP and Poitras K. Aspartame-induced lobular panniculitis.
J Am Acad Dermatol 24:298-300,
1991.
24.
McCauliffe, DP, Gardner D. Ro/SS-A autoantibodies reactivity with
recombinant 60, 52 and 46 kD fusion proteins. J Invest Dermatol 98:630, 1992.
25.
Sontheimer RD, McCauliffe DP, Wilson JL, Capra JD. Transcriptional
regulation of human calreticulin. J
Invest Dermatol 98:628, 1992.
26.
McCauliffe DP, Yang YS, Wilson J, Sontheimer RD, Capra JD. The 5'
flanking region of the human calreticulin gene is highly homologous with the
human GRP78, GRP94 and protein disulfide isomerase promoters. J Biol Chem 267:2557-2562, 1992.
27.
McCauliffe DP, Sontheimer RD. Subacute cutaneous lupus
erythematosus. In: Wallace DJ
and Hahn BH, editors. Dubois' Lupus Erythematosus. Philadelphia,
Lea & Febiger, 302-309, 1992.
28.
Sontheimer RD, McCauliffe DP, Zappi E, Targoff IN. The fine
specificity of rheumatic disease-associated autoantibodies. Advances in Dermatology 7:3-52,
1992. Chicago: Year Book Medical Publishers, Inc.
29.
Black AA, McCauliffe DP, Sontheimer RD. Prevalence of acne rosacea
in a rheumatic skin disease subspecialty clinic. Lupus 1:229-237, 1992.
30.
Lux FA, McCauliffe DP, Buttner DW, Capra JD, Sontheimer RD, Lieu TS.
Serologic cross-reactivity between a human Ro/SS-A autoantigen
(calreticulin) and the Ral-1 antigen of Onchocerca
volvulus. J Clin Invest
89:1945-1951, 1992.
31.
McCauliffe DP, Sontheimer RD. Molecular studies of the Ro/SS-A
autoantigens. Pages 798-804
In: Dermatology Progress
& Perspectives; eds: Burgdorf WHC and Katz SI. Parthenon Publishing Group, Inc.,
Pearl River, New York, 1992.
32.
Lucas L, Yin H, McCauliffe DP. 52 and 60 kD Ro/SS-A autoantigens are
expressed by human keratinocytes and are reactive with subacute cutaneous
and neonatal lupus erythematosus sera. J
Invest Dermatol 100:575, 1993.
33.
Lowen L, McCauliffe DP. The 52 kD Ro/SS-A autoantigen binds DNA with
high affinity and is a member of a novel family of zinc finger proteins. J Invest Dermatol 100:553, 1993.
34.
McCauliffe DP, Sontheimer RD. Molecular characterization of the
Ro/SS-A autoantigens. J Invest Dermatol 100:73S-79S,
1993.
35.
McCauliffe DP and Sontheimer RD. Dermatologic Manifestations of
Rheumatic Disorders. Primary Care
20:925-941, 1993.
36.
Cornelius PB, McCauliffe DP. Detection of Ro/SS-A autoantibodies in
dermatomyositis sera. J Invest
Dermatol 102:635, 1994.
37.
McCauliffe DP, Yin H, Wang L, Lucas L. Subacute cutaneous and
neonatal lupus
erythematosus sera react with multiple epitopes on the 52 and 60 kD
Ro/SS-A autoantigens. J Invest
Dermatol 102:635, 1994.
38.
McCauliffe DP, Lupus erythematosus-specific cutaneous disease. Keio J Med 43:225, 1994.
39.
McCauliffe DP, Yin Y, Wang L, Lucas L. Autoimmune sera react with
multiple epitopes on recombinant 52 and 60 kD Ro/SS-A proteins. J Rheumatol 21:1073-1080, 1994.
40.
Satoh M, Langdon JJ, Chou CH, McCauliffe DP, Treadwell EL, Ogasawara
T, Hirakata M, Suwa A, Cohen PL, Eisenberg RA, Reeves WH. Characterization
of the Su antigen, a macromolecular complex of 100/102 and 200-kDa proteins
recognized by autoantibodies in systemic rheumatic diseases. Clin Immunol Immunopathol
73:132-141, 1994.
41.
McCauliffe, DP. The autoantibodies of neonatal lupus erythematosus. J Invest Dermatol 102: 827, 1994.
42.
Yell JA, Wang L, Yin H, McCauliffe DP. The location of the 60 and 52
kD Ro (SS-A) antigens in human keratinocytes. J Invest Dermatol 104:641, 1995.
43.
McCauliffe DP, Guest PJ, Folds JD. Cytoplasmic fluorescence on
routine ANA testing is frequently associated with anti-60 kD Ro/SS-A
autoantibodies. J Invest Dermatol
104:679, 1995.
44.
McCauliffe DP. Neonatal Lupus Erythematosus: A transplacentally
acquired autoimmune disorder. Semin
Dermatol 14: 47-53, 1995.
45.
McCauliffe DP, Wang L, Small D. A recombinant 52 kD Ro(SS-A) ELISA
detects autoantibodies in primary Sjogren’s syndrome sera that go
undetected by conventional serologic assays. Arthritis Rheum 39:S181, 1996.
46.
Yell, JA, Wang, L, Yin H, McCauliffe DP. 52 and 60 kD Ro/SS-A
autoantigens have disparate intracellular locations in human keratinocytes.
Arthritis Rheum 39:S181, 1996.
47.
McCauliffe DP, Faircloth E, Wang L, Hashimoto T, Hoshino Y,
Nishikawa T. Similar Ro/SS-A autoantibody epitope and titer responses in
annular erythema of Sjogren’s syndrome and subacute cutaneous lupus
erythematosus. Arch Dermatol
32:528-531, 1996.
48.
Yell JA, Wang L, Yin H, McCauliffe DP. Disparate locations of the 52
and 60 kD Ro/SS-A antigens in cultured human keratinocytes. J Invest Dermatol 107:622-626,
1996.
49.
McCauliffe, DP.
Antibody penetration into the cells of mice and men. J Invest Dermatol 107:3-4, 1996.
50.
McCauliffe DP, Sontheimer RD. Cutaneous lupus erythematosus. Pages
67-82. In: The Clinical Management
of Systemic Lupus Erythematosus, Ed: Schur PH. Lippincott-Raven
Publishers, New York, 1996.
51.
McCauliffe DP, Wang L, Satoh M, Reeves W, Small D. Anti-52 kD
Ro(SS-A) autoantibodies go undetected by conventional Ro Serologic assays. J Invest Dermatol 108: 640, 1997.
52.
McCauliffe DP, Wang L, Satoh M, Reeves WH, Small D. A recombinant 52 kD Ro(SS-A) ELISA
detects autoantibodies in Sjogren’s Syndrome sera that go undetected by
conventional serologic assays. J
Rheumatol 24:860-6, 1997.
53.
McCauliffe DP. Cutaneous associations of anti-Ro/SS-A autoantibody
production in adults. Lupus 6:158-166, 1997.
54.
Skidmore RA, Davis DA, Woosley JT and McCauliffe DP. Massive
dystrophic calcinosis cutis secondary to chronic needle trauma. Cutis 60:259-62, 1997.
55.
McCauliffe DP. Distinguishing subacute cutaneous from other types of
lupus erythematosus. Lancet
351:1527-8, 1998.
56.
Franceschini F, Calzavara-Pinton P, Quinzanini M, Cavazzana I,
Bettoni L, Zane C, Facchetti F, Airň P, McCauliffe DP, Cattaneo R. Chilblain lupus erythematosus is
associated with antibodies to SSA/Ro. Lupus
8:215-219, 1999.
57.
Gahli F, Groben P, McCauliffe DP. Panniculitis in juvenile
dermatomyositis. Pediatr Dermatol,
16:270-2, 1999.
58.
Gahli F., Stein L, McCauliffe DP. Rediscovery of gingival
telangiectasias as a cutaneous marker for juvenile dermatomyositis. Arch Dermatol 135:1370-74, 1999.
59.
Sweeny AL, McCauliffe DP.
52 Ro/SS-A protein resides along cytokeratin filaments in epithelial
cells. J Invest Dermatol 114:856, 2000.
60.
Lopez M, Wozniacka A, McCauliffe DP. 52 Ro/SS-A protein resides along cytokeratins and other
intermediate filaments. Arthritis Rheum in press, 2000.
61.
McCauliffe DP. Neonatal Lupus Erythematosus, In: Textbook of Paediatric Dermatology,
edited by Harper J, Oranje A, and Prose N. Blackwell Science Ltd, Oxford.
Pages 111-6, 2000.
62.
Jewell M, McCauliffe DP.
Cutaneous lupus erythematosus patients that smoke are less
responsive to antimalarial treatment.
J Am Acad Dermatol
42:983-7, 2000.
63.
Morrell DS, Ghali FE, Stahr BJ, McCauliffe DP. Eccrine angiomatous
hamartoma: A report of symmetric and painful lesions of the wrists. Pediatr Dermatol 18:117-9,
2001.
64.
McCauliffe DP. Cutaneous lupus erythematosus. Semin Cutan Med
Surg 20:14-26, 2001.
65.
McCauliffe DP, Sontheimer RD.
Cutaneous lupus erythematosus.
Pages 573-618. In: Wallace DJ and Hahn BH, editors. Dubois' Lupus Erythematosus, 5th
edition. Philadelphia.
Lippincott, Williams & Wilkins, in press, 2002.
66.
Wozniacka A, Carter A, McCauliffe DP. Mechanisms by which
antimalarials may provide therapeutic benefit in cutaneous lupus
erythematosus. Lupus, in press, 2002.
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